Therapeutic drug monitoring and toxicity tests

Diomune S.L. develops in vivo preclinical trials to evaluate the safety and efficacy of drugs of interest and to establish the optimal treatment regimens for patient’s benefit.
Measuring vital signs:

  • Body weight
  • Body temperature
  • Organo somatic index

Measurement of serum creatinine and analysis of blood urea nitrogen (BUN)

  • Measurement of creatinine in urine
  • Calculation of creatinine clearance

Compartmental pharmacokinetics:

Administration:
– Enteral: oral, rectal
– Parenteral: intravenous, intramuscular, subcutaneous, intraperitoneal, topical, intrathecal, pulmonary.
Absorption: fraction measurement and the speed at which the administered dose of a drug reaches its therapeutic target (bioavailability)
Distribution: measurement of the concentration of a drug in biological fluids and organs at different times after administration
Metabolism and Excretion:
– Elimination constant
– Elimination
Minimum Level Anticipated Biological Effect (MABEL) calculation: concentration determination of safe use and desired therapeutic effect of the drug for the establishment of optimal treatment for the patient.

 

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